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Neurobiology of Alcohol Dependence

Neurobiology of Alcohol Dependence
Author: Antonio Noronha, Changhai Cui, Robert Adron Harris, John C. Crabbe
Publisher: Elsevier
ISBN: 0124071554
Pages: 566
Year: 2014-05-02
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Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available

Behavioral Neurobiology of Alcohol Addiction

Behavioral Neurobiology of Alcohol Addiction
Author: Wolfgang Sommer, Rainer Spanagel
Publisher: Springer Science & Business Media
ISBN: 3642287204
Pages: 727
Year: 2012-07-28
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The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.

Neurobiology of Addiction

Neurobiology of Addiction
Author: George F. Koob, Michel Le Moal
Publisher: Elsevier
ISBN: 0080497373
Pages: 504
Year: 2005-11-11
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Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

The Science of Addiction: From Neurobiology to Treatment

The Science of Addiction: From Neurobiology to Treatment
Author: Carlton K. Erickson
Publisher: W. W. Norton & Company
ISBN: 0393076229
Pages: 312
Year: 2007-02-17
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Runner-up winner of the Hamilton Book Author Award, this book is a comprehensive overview of the neurobiology behind addictions. Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. The Science of Addiction presents a comprehensive overview of the roles that brain function and genetics play in addiction. It explains in an easy-to-understand way changes in the terminology and characterization of addiction that are emerging based upon new neurobiological research. The author goes on to describe the neuroanatomy and function of brain reward sites, and the genetics of alcohol and other drug dependence. Chapters on the basic pharmacology of stimulants and depressants, alcohol, and other drugs illustrate the specific and unique ways in which the brain and the central nervous system interact with, and are affected by, each of these substances Erickson discusses current and emerging treatments for chemical dependence, and how neuroscience helps us understand the way they work. The intent is to encourage an understanding of the body-mind connection. The busy clinical practitioner will find the chapter on how to read and interpret new research findings on the neurobiological basis of addiction useful and illuminating. This book will help the almost 21.6 million Americans, and millions more worldwide, who abuse or are dependent on drugs by teaching their caregivers (or them) about the latest addiction science research. It is also intended to help addiction professionals understand the foundations and applications of neuroscience, so that they will be able to better empathize with their patients and apply the science to principles of treatment.

Research on the Neurobiology of Alcohol Use Disorders

Research on the Neurobiology of Alcohol Use Disorders
Author: Leo Sher
Publisher: Nova Publishers
ISBN: 1604561971
Pages: 372
Year: 2008
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This book describes the neurobiological mechanisms of alcohol abuse and dependence including the role of serotonergeic, dopaminergic, noradrenergic, and hypothalamic-piturary adrenal systems in alcohol use disorders and the results of neuroimaging studies are presented. The neurobiology of comorbidity of alcohol use disorders with other psychiatric disorders are also discussed. Research on the neurobiology of alcohol abuse and dependence is very important. Therefore, this book will be of interest to biomedical researchers, physicians, and other clinicians, students, and anyone who is interested in the mechanisms of addictive disorders.

Drugs, Addiction, and the Brain

Drugs, Addiction, and the Brain
Author: George F. Koob, Michael A. Arends, Michel Le Moal
Publisher: Academic Press
ISBN: 0123869595
Pages: 350
Year: 2014-07-12
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Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction

Addictive Substances and Neurological Disease

Addictive Substances and Neurological Disease
Author: Ronald Ross Watson, Sherma Zibadi
Publisher: Academic Press
ISBN: 0128092963
Pages: 414
Year: 2017-02-18
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Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances. Integrates current research on the actions of addictive substances in neurological disease Includes functional foods, such as caffeine beverages, that have habituating effects on the brain Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances

Alcohol and the Nervous System

Alcohol and the Nervous System
Author: Adolf Pfefferbaum, Edith V. Sullivan
Publisher: Elsevier
ISBN: 0444626190
Pages: 704
Year: 2014-11-01
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Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. * The first focused reference specifically on alcohol and the brain * Details our current understanding of how alcohol impacts the central nervous system * Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse * Includes section on neuroimaging of neurochemical markers and brain function

Addiction Neuroethics

Addiction Neuroethics
Author: Adrian Carter, Wayne Hall
Publisher: Cambridge University Press
ISBN: 1139504673
Pages:
Year: 2011-11-17
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Addiction is a significant health and social problem and one of the largest preventable causes of disease globally. Neuroscience promises to revolutionise our ability to treat addiction, lead to recognition of addiction as a 'real' disorder in need of medical treatment and thereby reduce stigma and discrimination. However, neuroscience raises numerous social and ethical challenges: • If addicted individuals are suffering from a brain disease that drives them to drug use, should we mandate treatment? • Does addiction impair an individual's ability to consent to research or treatment? • How will neuroscience affect social policies towards drug use? Addiction Neuroethics addresses these challenges by examining ethical implications of emerging neurobiological treatments, including: novel psychopharmacology, neurosurgery, drug vaccines to prevent relapse, and genetic screening to identify individuals who are vulnerable to addiction. Essential reading for academics, clinicians, researchers and policy-makers in the fields of addiction, mental health and public policy.

Stress and Addiction

Stress and Addiction
Author: Mustafa al'Absi
Publisher: Elsevier
ISBN: 0080525296
Pages: 456
Year: 2011-04-28
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Stress is one of the most commonly reported precipitants of drug use and is considered the number one cause of relapse to drug abuse. For the past several decades, there have been a number of significant advances in research focusing on the neurobiological and psychosocial aspects of stress and addiction; along with this growth came the recognition of the importance of understanding the interaction of biological and psychosocial factors that influence risk for initiation and maintenance of addictive behaviors. Recent research has started to specifically focus on understanding the nature of how stress contributes to addiction - this research has influenced the way we think about addiction and its etiological factors and has produced exciting possibilities for developing effective intervention strategies; to date there has been no available book to integrate this literature. This highly focused work integrates and consolidates available knowledge to provide a resource for researchers and practitioners and for trainees in multiple fields. Stress and Addiction will help neuroscientists, social scientists, and mental health providers in addressing the role of stress in addictive behaviors; the volume is also useful as a reference book for those conducting research in this field. Integrates theoretical and practical issues related to stress and addiction Includes case studies illustrating where an emotional state and addictive behavior represent a prominent feature of the clinical presentation Cross-disciplinary coverage with contributions by by scientists and practitioners from multiple fields, including psychology, neuroscience, neurobiology, and medicine

Neuroscience of Psychoactive Substance Use and Dependence

Neuroscience of Psychoactive Substance Use and Dependence
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241562358
Pages: 264
Year: 2004
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Neuroscience of Psychoactive Substance Use and Dependence provides an authoritative summary of current knowledge of the biological basis of substance use behaviours including their relationship with environmental factors. The report focuses on a wide range of psychoactive substances including tobacco alcohol and illicit drugs. New developments in neuroscience research are discussed (e.g. mechanisms governing craving tolerance neuroadaptation immunotherapies and the concept of dependence) as well the ethical implications of these developments. As the product of consultations with and contributions from many international experts and partners the best available evidence is provided from the various schools of thought and areas of research in the field of neuroscience. The most comprehensive overview on substance abuse written to date is provided in this book.... - The Annals of Pharmacotherapy Neuroscience of Psychoactive Substance Use and Dependence is targeted at individuals with more than a basic knowledge of neuroscience including scientists from a number of disciplines. It is expected that this publication will be of interest to health care workers clinicians social workers university students science teachers and informed policy makers. ...This is an outstanding publication with a very useful text for workers and researchers in the filed of substance abuse and dependence especially psychiatrists psychologists or trainees in these fields.... - South African Medical Journal

Neurobiology of Alcohol Dependence

Neurobiology of Alcohol Dependence
Author: Antonio Noronha, Changhai Cui, Robert Adron Harris, John C. Crabbe
Publisher: Elsevier
ISBN: 0124071554
Pages: 566
Year: 2014-05-02
View: 840
Read: 199

Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available

Alcohol Problems in Adolescents and Young Adults

Alcohol Problems in Adolescents and Young Adults
Author: Marc Galanter
Publisher: Springer Science & Business Media
ISBN: 0306486261
Pages: 456
Year: 2006-03-30
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Alcohol continues to be the substance of choice for today’s youth, leading to serious physical, psychological, and social consequences. Alcohol Problems in Adolescents and Young Adults ably addresses this growing trend. The latest entry in the Recent Developments in Alcoholism series, it comprehensively presents a wide-ranging clinical picture of teen drinking - epidemiology, neurobiology, behavioral phenomena, diagnostic and assessment issues, prevention and treatment data - in a developmental context. Fifty expert contributors display the scientific rigor, practical wisdom, and nuanced analysis that readers have come to expect from previous volumes. Among the subjects studied in depth: - Initiation of alcohol use/abuse - Risk and protective factors for alcohol dependence - High-risk adolescent populations - Drinking habits of college students - Long-range consequences of teenage drinking - Family-, school-, and community-based prevention programs - Treatment of comorbid substance and psychiatric disorders Clinicians, researchers, and policy makers will find this a bedrock source of evidence-based knowledge, whether one’s goal is choosing an age-appropriate assessment tool for eighth graders, preventing drinking among high school students, or understanding the alcohol-friendliness of campus culture. Here is a critical resource for all professionals dedicated to helping youngsters grow up sober.

Advances in the Neuroscience of Addiction

Advances in the Neuroscience of Addiction
Author: Cynthia M. Kuhn, George F. Koob
Publisher: CRC Press
ISBN: 1420007351
Pages: 238
Year: 2010-04-12
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Understanding the phenomenon of long-lasting vulnerability to addiction is essential to developing successful treatments. Written by an international team of authorities in their respective fields, Advances in the Neuroscience of Addiction provides an excellent overview of the available and emerging approaches used to investigate the biologic mechanisms of drug addiction. It also delineates the promising research discoveries being made in relapse prevention. The book begins with current animal models of addiction, which mimic the state of humans entering treatment: recently-abstinent animals that receive common triggers for relapse (classical conditioning, stress, and neuroadaptive dysregulation). Coverage then shifts to the use of electrophysiologic approaches, which enable researchers to characterize the discharge patterns of single neurons during drug self-administration. After exploring advances in voltammetry and enzyme-linked biosensors for measuring glutamate, the book discusses the theoretical background and results of neuroimaging studies related to neuronal networks that are activated by drug-specific cues. It then describes modern genetic approaches to manipulate target proteins that influence addictive behavior. The book rounds out its coverage by illustrating how a neuroeconomic approach can inform studies of reward processing in general and addiction in particular. It is a comprehensive introduction to the methodologies of the field for students and beginning researchers and an essential reference source for established investigators.

The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption

The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption
Author:
Publisher: Academic Press
ISBN: 0128124741
Pages: 304
Year: 2017-10-31
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The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption, Volume 136 in the International Review of Neurobiology series, provides an overview of the top candidate neuropeptides in the modulation of alcohol and drug abuse, also covering eating disorders and obesity. Topics covered in this latest release include Corticotropin Releasing Factor (CRF) and Addictive Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role of Ghrelin Signaling in Additive Behaviors, The Role of the Melanocortin System in Drug and Eating Disorders, Substance P and the Neurokinin-1 Receptor: The New CRH, and the Role of Neuropeptide Y (NPY) in Drug and Eating Disorders. The book uniquely highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders. Presents a recent overview of some of the top candidate neuropeptides in the modulation of alcohol and drug abuse, and in eating disorders and obesity Highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders Contains chapters that focus on a specific neuropeptide

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